AMAB Hypogonadism is a form of hypogonadism leading to a reduction in the output of male sex hormones in AMAB people due to decreased functionality of the testes. Hypogonadism can be primary, meaning it's caused by a problem with the testicles, or it can be secondary hypogonadism, meaning it's caused by a problem with the signals sent from the brain to the testicles.
Symptoms will include the effects of low testosterone, such as low energy, fatigue, low muscle tone, and a lower sex drive (unless they are on the ace-spectrum already.) Those with congenital hypogonadism are usually diagnosed because they will not have started puberty.
It is important to note that not all the symptoms listed above are guaranteed to occur in someone with this condition, as someone may only experience one or several of these symptoms, yet still hold the condition.
Causes
Hypogonadism can be congenital or it can be acquired. Acquired hypogonadism may be caused by infections, radiation, certain autoimmune disorders, some chronic illnesses, severe stress, or damage to the pituitary gland (through drugs, radiation, or surgery.)
Congenital hypogonadism may, in some cases, be caused by the conditions listed below:
- Gene mutations
- Chromosomal abnormalities
- Horomonal abnormalities (such as increased estrogen)
- 17-AH Deficiency
- 17-KSR Deficiency
- 49,XXXXY Syndrome
- Aromatase Deficiency
- Cryptorchidism or Micropenis
- Cytochrome PORD
- De La Chapelle Syndrome
- Denys-Drash Syndrome
- Gonadal Agenesis
- Gonadal Dysgenesis
- H Syndrome
- Kallman Syndrome
- Klinefelter Syndrome
- Leydig Cell Hypoplasia
- MDP Syndrome
- PMDS
- PPSH
- XXXY Syndrome
- XYYY Syndrome
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