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    Leydig Cell Hypoplasia or LCH is an extremely rare intersex variation[1] that effects AMAB/CTM individuals in which the Leydig Cell (a cell that secretes androgens) is underdeveloped.[2]

    The cells underdevelopment causes a decrease in androgens and may cause ones male traits to be more feminine in nature.

    One with this variation tends to have ambiguous genitals, micropenis, a penis with hypospadias and/or a bifid scrotum, decreased body hair, and decreased muscle tone. In more extreme cases, they may have a vagina, with their testicles being small (microorchidism) and undescended (cryptorchidism).

    Often AMAB hypogonadism is seen in these individuals as well, which may cause them to also fall under aromatase excess syndrome.[3][4]

    References

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