Not to be confused with XXYYY Syndrome or XXYY Syndrome.
49,XXXYY syndrome is a a intersex variation in which a CTM individual has two extra X chromosomes and one extra Y chromosome. It is a very rare variation amongst DMAB individuals, and it has no estimated rarity.
Symptoms of this include an abnormal face shape, a prominent forehead, widely spaced eyes, epicanthic folds, broad nasal bridge, prognathism, low-set rotated ears, a small jaw, club feet, abnormal feet prints, AMAB hypogonadism, breast growth, delayed skeletal maturation, microorchidism, a micropenis, and/or ambiguous genitallia.
Those with this variation tend to also have autism or be otherwise neurodivergent. This condition is considered similar to klinefelter syndrome, and may or may not be considered a variation of it as well.
It is important to note that not all the symptoms listed in this page are guaranteed to occur in someone with this variation, as someone may only experience one or several of these symptoms, yet still hold the variation.