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    49,XXXYY syndrome is an intersex variation in which a CTM individual has two extra X chromosomes and one extra Y chromosome. It is a very rare variation amongst DMAB individuals, and it has no estimated rarity.[1]

    Symptoms of this include an abnormal face shape, a prominent forehead, widely spaced eyes, epicanthic folds, broad nasal bridge, prognathism, low-set rotated ears, a small jaw, club feet, abnormal feet prints, AMAB hypogonadism, breast growth, delayed skeletal maturation, microorchidism, a micropenis, and/or ambiguous genitalia.

    Those with this variation tend to also have autism or be otherwise neurodivergent. This condition is considered similar to klinefelter syndrome, and may or may not be considered a variation of it as well.

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