49,XXYYY syndrome is an intersex variation in which a CTM individual has two extra Y chromosomes and one extra X chromosome. It is a very rare variation amongst DMAB individuals, and it has no estimated rarity.
Those with this variation tend to have facial dysmorphism, mild microcephaly, limitation of supination at the elbows, delayed bone age, and moderate intellectual disability.[1] This variation is often considered a subset of Klinefelter syndrome. If these symptoms cause any physical struggles, they may be classified as physically disabled.
Studies
Medical professionals looked into tissues sampled for chromosome studies of external ambiguous genitalia and abdominal gonads, consisting of a left ovotestis and a right primitive testis, and found that they contained cells 46,XX, 47,XXY and 49,XXYYY sex chromosomes.[2] This implies that those with ambiguous genitalia and/or ovotestes may - in some cases - hold the genetic materiel to bare, grow, or develop a child with XXYYY syndrome (if they can ovulate and/or produce sperm).