AFAB Hypogonadism is a form of hypogonadism leading to a reduction in the output of female sex hormones including estrogen and progesterone in AFAB people, due to decreased functionality of the ovaries. Hypogonadism can be primary, meaning it's caused by a problem with the ovaries, or it can be secondary hypogonadism, meaning it's caused by a problem with the signals sent from the brain to the ovaries.
Hypogonadism can be congenital or it can be acquired. Congenital hypogonadism can be caused by Turner syndrome, gene mutations, chromosomal abnormalities, or other conditions of intersex. This form of is typically not noticed until the onset of puberty. Acquired hypogonadism may be caused by infections, radiation, certain autoimmune disorders, some chronic illnesses, or damage to the pituitary gland.
Symptoms will include the effects of low estrogen. Those with congenital hypogonadism will not begin menstruation and will having slow or absent breast growth. Those with acquired hypogonadism will stop menstruating and will experience symptoms of menopause, including lowered sex drive, loss of body hair, and hot flashes.