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'''49,XYYYY''' '''syndrome''' is a rare [[intersex]] variation in which an [[CTM]] individual has three extra Y chromosomes instead of just the usual one. It is estimated to occur in 1 in 1,000,000 [[AMAB|DMAB]] children. Due to the rarity, little is known about this variation. |
'''49,XYYYY''' '''syndrome''' is a rare [[intersex]] variation in which an [[CTM]] individual has three extra Y chromosomes instead of just the usual one. It is estimated to occur in 1 in 1,000,000 [[AMAB|DMAB]] children. Due to the rarity, little is known about this variation. |
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Symptoms of this variation includes speech delay, [[Secondary Sex Agenesis|hypotonia (low muscle tone)]], including facial asymmetry, hypertelorism, bilateral low set ‘lop’ ears, a incurved pinky, widely spaced eyes, fusion within the bones of the forearm, and an undersized jaw. Those with the variation also typically fall on the autism spectrum and/or have ADHD. |
Symptoms of this variation includes speech delay, [[Secondary Sex Agenesis|hypotonia (low muscle tone)]], including facial asymmetry, hypertelorism, bilateral low set ‘lop’ ears, a incurved pinky, widely spaced eyes, fusion within the bones of the forearm, and an undersized jaw. Those with the variation also typically fall on the [[Neurodivergent|autism spectrum and/or have ADHD]].<ref>https://bmcmedgenet.biomedcentral.com/articles/10.1186/s12881-017-0371-1</ref><ref>https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99330</ref> |
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It is important to note that not all the symptoms listed in this page are guaranteed to occur in someone with this variation, as someone may only experience one or several of these symptoms, yet still hold the variation. |
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== History == |
== History == |
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XYYYY syndrome was first recorded in 1981 in a 14-month-old AMAB child. |
XYYYY syndrome was first recorded in 1981 in a 14-month-old AMAB child.<ref>https://en.wikipedia.org/wiki/XYYYY_syndrome#History</ref> |
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== Flag == |
== Flag == |
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The flag was coined on February 19, 2019 by Ap through Tumblr user beyond-mogai-pride-flags account. It has no confirmed meaning, however it closely resembles the [[XYYY Syndrome|XYYY]] flag, just with a fourth Y.<ref>[https://beyond-mogai-pride-flags.tumblr.com/post/182928029210/49xyyyy-pride-flag Beyond MOGAI Pride Flags — XYYYY Pride Flag]</ref> |
The flag was coined on February 19, 2019 by Ap through Tumblr user beyond-mogai-pride-flags account. It has no confirmed meaning, however it closely resembles the [[XYYY Syndrome|XYYY]] flag, just with a fourth Y.<ref>[https://beyond-mogai-pride-flags.tumblr.com/post/182928029210/49xyyyy-pride-flag Beyond MOGAI Pride Flags — XYYYY Pride Flag]</ref> |
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== |
== References == |
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* [https://pubmed.ncbi.nlm.nih.gov/9805123/ An adult with 49,XYYYY karyotype: case report and endocrine studies - PubMed (nih.gov)] |
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*https://en.wikipedia.org/wiki/XYYYY_syndrome |
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* [https://en.wikipedia.org/wiki/XYYYY_syndrome XYYYY syndrome - Wikipedia] |
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*https://bmcmedgenet.biomedcentral.com/articles/10.1186/s12881-017-0371-1 |
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* [https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99330 Orphanet: 49,XYYYY syndrome] |
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[[Category:Intersex Traits]] |
[[Category:Intersex Traits]] |
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