(Adding categories) |
Cryptocrew (talk | contribs) (Added information that was left out.) |
||
| (15 intermediate revisions by 6 users not shown) | |||
| Line 1: | Line 1: | ||
:''{{Distinguish|XYYY Syndrome}}'' |
|||
{{Distinguish|3=XYYY Syndrome}}'''49,XYYYY''' '''syndrome''' is a rare Y chromosomal number [[intersex]] [[CTM]]/[[AMAB|DMAB]] variation with a variable phenotype mainly characterized by moderate to severe intellectual disability, speech delay, hypotonia, and mild dysmorphic features, including facial asymmetry, hypertelorism, bilateral low set ‘lop’ ears, and micrognatia.<ref>[https://beyond-mogai-pride-flags.tumblr.com/post/182928029210/49xyyyy-pride-flag Beyond MOGAI Pride Flags — XYYYY Pride Flag]</ref> |
|||
[[File:Xyyyy.png|thumb|The XYYYY Syndrome flag.]] |
|||
'''49,XYYYY''' '''syndrome''' is a rare [[intersex]] variation in which an [[CTM]] individual has three extra Y chromosomes instead of just the usual one. It is estimated to occur in 1 in 1,000,000 [[AMAB|DMAB]] children. Due to the rarity, little is known about this variation. |
|||
Traits of this variation includes speech delay, [[Secondary Sex Agenesis|hypotonia (low muscle tone)]], including facial asymmetry, hypertelorism, bilateral low set ‘lop’ ears, a incurved pinky, widely spaced eyes, fusion within the bones of the forearm, and an undersized jaw. Those with the variation also typically fall on the [[Neurodivergent|autism spectrum and/or have ADHD]].<ref>https://bmcmedgenet.biomedcentral.com/articles/10.1186/s12881-017-0371-1</ref> [[AMAB Hypogonadism|Hypogonadism]] is also known to occur with this variation.<ref>https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99330</ref> |
|||
== External links == |
|||
== History == |
|||
* [https://pubmed.ncbi.nlm.nih.gov/9805123/ An adult with 49,XYYYY karyotype: case report and endocrine studies - PubMed (nih.gov)] |
|||
XYYYY syndrome was first recorded in 1981 in a 14-month-old AMAB child.<ref>https://en.wikipedia.org/wiki/XYYYY_syndrome#History</ref> |
|||
* [https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99330 Orphanet: 49,XYYYY syndrome] |
|||
== Flag == |
|||
The flag was coined on February 19, 2019 by Ap through Tumblr user beyond-mogai-pride-flags account. It has no confirmed meaning, however it closely resembles the [[XYYY Syndrome|XYYY]] flag, just with a fourth Y.<ref>[https://beyond-mogai-pride-flags.tumblr.com/post/182928029210/49xyyyy-pride-flag Beyond MOGAI Pride Flags — XYYYY Pride Flag]</ref> |
|||
== References == |
|||
[[Category:Intersex Traits]] |
[[Category:Intersex Traits]] |
||
<references /> |
|||
[[Category:Sex Category]] |
|||
[[Category:Verified Resources]] |
|||
Latest revision as of 18:14, 21 January 2023
49,XYYYY syndrome is a rare intersex variation in which an CTM individual has three extra Y chromosomes instead of just the usual one. It is estimated to occur in 1 in 1,000,000 DMAB children. Due to the rarity, little is known about this variation.
Traits of this variation includes speech delay, hypotonia (low muscle tone), including facial asymmetry, hypertelorism, bilateral low set ‘lop’ ears, a incurved pinky, widely spaced eyes, fusion within the bones of the forearm, and an undersized jaw. Those with the variation also typically fall on the autism spectrum and/or have ADHD.[1] Hypogonadism is also known to occur with this variation.[2]
History
XYYYY syndrome was first recorded in 1981 in a 14-month-old AMAB child.[3]
Flag
The flag was coined on February 19, 2019 by Ap through Tumblr user beyond-mogai-pride-flags account. It has no confirmed meaning, however it closely resembles the XYYY flag, just with a fourth Y.[4]