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'''XXYY''' or '''48,XXYY syndrome''' or '''48,XXYY''' is a rare [[CTM]] [[intersex]] trait occurring in approximately 1 in 18,000 to 1 in 40,000 people [[Assigned Gender|assigned male at birth]].<ref>https://ghr.nlm.nih.gov/condition/48xxyy-syndrome#</ref> It is a chromosomal condition that causes them to have an extra X and an extra Y chromosome (XXYY). It may be considered a variant of [[Klinefelter Syndrome|Klinefelter syndrome]]. |
'''XXYY''' or '''48,XXYY syndrome''' or '''48,XXYY''' is a rare [[CTM]] [[intersex]] trait occurring in approximately 1 in 18,000 to 1 in 40,000 people [[Assigned Gender|assigned male at birth]].<ref>https://ghr.nlm.nih.gov/condition/48xxyy-syndrome#</ref> It is a chromosomal condition that causes them to have an extra X and an extra Y chromosome (XXYY). It may be considered a variant of [[Klinefelter Syndrome|Klinefelter syndrome]]. |
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Those with the the condition typically have [[Agenital|small testes]] that do not produce enough testosterone, which can lead to reduced facial and body hair, poor muscle development, breast growth, and infertility. Other common symptoms can include increased height, dental problems, problems with blood vessels in the legs, difficulty with language development, delayed development of motor skills, tremors that typically start in adolescence and increase with age, and an increased likelihood of several other physical and neurological conditions.<ref>https://rarediseases.info.nih.gov/diseases/5677/48xxyy-syndrome</ref> They typically also have [[AMAB Hypogonadism|AMAB hypogonadism]], and might also be classified under [[Aromatase Excess Syndrome|aromatase excess syndrome]]. |
Those with the the condition typically have [[Agenital|small testes]] that do not produce enough testosterone, which can lead to reduced facial and body hair, [[Secondary Sex Agenesis|poor muscle development]], breast growth, and infertility. Other common symptoms can include increased height, dental problems, problems with blood vessels in the legs, difficulty with language development, delayed development of motor skills, tremors that typically start in adolescence and increase with age, and an increased likelihood of several other physical and neurological conditions.<ref>https://rarediseases.info.nih.gov/diseases/5677/48xxyy-syndrome</ref> They typically also have [[AMAB Hypogonadism|AMAB hypogonadism]], and might also be classified under [[Aromatase Excess Syndrome|aromatase excess syndrome]]. |
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== History == |
== History == |
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