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'''49,XYYYY''' '''syndrome''' is a rare [[intersex]] variation in which an [[CTM]] individual has three extra Y chromosomes instead of just the usual one. It is estimated to occur in 1 in 1,000,000 [[AMAB|DMAB]] children. Due to the rarity, little is known about this variation.
Symptoms of this variation includes speech delay, [[Secondary Sex Agenesis|hypotonia (low muscle tone)]], including facial asymmetry, hypertelorism, bilateral low set ‘lop’ ears, a incurved pinky, widely spaced eyes, fusion within the bones of the forearm, and an undersized jaw. Those with the variation also typically fall on the [[Neurodivergent|autism spectrum and/or have ADHD]].<ref>https://bmcmedgenet.biomedcentral.com/articles/10.1186/s12881-017-0371-1</ref><ref>https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99330</ref>
== History ==
XYYYY syndrome was first recorded in 1981 in a 14-month-old AMAB child.<ref>https://en.wikipedia.org/wiki/XYYYY_syndrome#History</ref>
== Flag ==
The flag was coined on February 19, 2019 by Ap through Tumblr user beyond-mogai-pride-flags account. It has no confirmed meaning, however it closely resembles the [[XYYY Syndrome|XYYY]] flag, just with a fourth Y.<ref>[https://beyond-mogai-pride-flags.tumblr.com/post/182928029210/49xyyyy-pride-flag Beyond MOGAI Pride Flags — XYYYY Pride Flag]</ref>
==
[[Category:Intersex Traits]]
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