[[File:Serkal syndrome flag.jpg|thumb|The SERKAL Syndrome flag.]]
'''SERKAL Syndrome''' is an [[intersex]] conditionvariation (similar to [[De La Chapelle Syndrome|de la chapelle syndrome]]) in which an individual has female[[müllerian]] chromosomes (XX) however they have a male[[wolffian]] appearance outwardly. This occurs in 1 in 1,000,000 [[CTM]] individuals.<ref>https://en.wikipedia.org/wiki/Serkal_syndrome</ref> This variation has only been reported in one family. All three fetuses with this variation were terminated during pregnancy.<ref>https://medlineplus.gov/genetics/gene/wnt4/#conditions</ref> <ref>https://www.omim.org/entry/611812</ref>
100% of those with this conditionvariation have growth delay, oligohydramnios, a small lung, an absent kidney, abnormalities in the nostrils, seizures, and oligohydramnios[[Neurodivergent|seizures]].
30%-79% of those witthwith this conditionvariation have abnormalities in the adrenal glands, a cleft in the mouth, ventricular septal defect, pulmonic stenosis, malrotation of the small bowel, an underdeveloped bladder, congenital diaphragmatic hernia, and genital abnormalities (such as having [[Agenital|cryptorchidism, a micropenis]], [[hypospadias]], and/or [[Penoscrotal Transposition|penoscrotal transposition]].)
Other symptoms include having [[Ovotesticular|ovotestes]], low-set ears, a cleft palate, and abnormal restriction within weight and growth as an infant. It is unknown how frequent these symptoms are.<ref>https://rarediseases.info.nih.gov/diseases/10302/serkal-syndrome#:~:text=SERKAL%20(SEx%20Reversion%2C%20Kidneys%2C,kidneys%2C%20adrenal%20glands%20and%20lungs.&text=The%20syndrome%20is%20lethal%20and%20has%20been%20described%20in%20three%20foetuses.&text=It%20is%20caused%20by%20homozygous%20missense%20mutations%20in%20the%20WNT4%20gene%20</ref>
== Causes ==
This conditionvariation is due to mutation in the ''Wnt4'' gene, which causes sex reversal that occurs during fetal development, in which gonad differentiation occurs. This means they were originally going to develop as female, however only the chromosomes did such, and the rest of the body developed in a malewolffian-like fashion.<ref>https://en.wikipedia.org/wiki/Serkal_syndrome#Genetics</ref>
== Resources Flag==
The SERKAL Syndrome flag was coined by [[User:Reign of the breadsticcs|Reign of the breadsticcs]] on May 7th of 2021. It has no confirmed meaning.<ref>https://lgbta.wikia.org/f/p/4400000000000137332/r/4400000000000449105</ref>
==References==
* https://en.wikipedia.org/wiki/Sex_reversal#:~:text=Sex%20reversal%20is%20a%20biological,and%20the%20sex%20phenotype%20expressed.
<references />
* https://rarediseases.info.nih.gov/diseases/10302/serkal-syndrome#:~:text=SERKAL%20(SEx%20Reversion%2C%20Kidneys%2C,kidneys%2C%20adrenal%20glands%20and%20lungs.&text=The%20syndrome%20is%20lethal%20and%20has%20been%20described%20in%20three%20foetuses.&text=It%20is%20caused%20by%20homozygous%20missense%20mutations%20in%20the%20WNT4%20gene%20.
* https://en.wikipedia.org/wiki/Serkal_syndrome
* https://www.omim.org/entry/611812
* https://monarchinitiative.org/disease/MONDO:0012734#phenotype
[[Category:Intersex Traits]]
[[Category:TerminologyVerified Resources]]
[[Category:FlaglessSex IdentitiesCategory]]
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