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[[File:Mdp flag.jpg|thumb|200x200px|The MDP Syndrome flag.]] |
[[File:Mdp flag.jpg|thumb|200x200px|The MDP Syndrome flag.]] |
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'''MDP Syndrome (Mandibular |
'''MDP Syndrome''' ('''Mandibular Hypoplasia-Deafness-Progeroid Syndrome''') is an [[intersex]] variation that effects both [[CTF]] and [[CTM]] individuals alike.<ref>https://rarediseases.info.nih.gov/diseases/10989/mandibular-hypoplasia-deafness-progeroid-features-and-lipodystrophy-syndrome</ref> |
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For CTM individuals, symptoms include [[Agenital|absent or undescended testicles]], [[AMAB Hypogonadism|AMAB hypogonadism]], and possibly [[Aromatase Excess Syndrome|aromatase excess syndrome]] due to the lack of testosterone. This may cause [[Secondary Sex Agenesis|low muscle tone]], low hair growth, and possibly [[feminine]] traits within these individuals |
For CTM individuals, symptoms include [[Agenital|absent or undescended testicles]], [[AMAB Hypogonadism|AMAB hypogonadism]], and possibly [[Aromatase Excess Syndrome|aromatase excess syndrome]] due to the lack of testosterone. This may cause [[Secondary Sex Agenesis|low muscle tone]], low hair growth, and possibly [[feminine]] traits within these individuals |
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For CTF individuals, symptoms include [[AFAB Hypogonadism|AFAB hypogonadism]] |
For CTF individuals, symptoms include [[AFAB Hypogonadism|AFAB hypogonadism]] and possibly [[hyperandrogenism]] due to the lack of estrogen. This may cause a lack of breast growth and possibly [[masculine]] traits within these individuals. |
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In both CTF and CTM individuals, common symptoms include deafness or low hearing, low fat, tight skin, a small lower jaw |
In both CTF and CTM individuals, common symptoms include deafness or low hearing, low fat, insulin resistance, diabetes, tight skin, a small lower jaw, an enlarged liver, flexed joints, dental crowding, and possibly a beaked nose. Some of the symptoms may classify one with this variation as physically [[disabled]]. |
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== Causes == |
== Causes == |
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This |
This variation is caused by a single codon deletion the ''POLD1'' gene, a gene that codes proteins and is present in all cells. This change can cause development in every cell to be different or impaired, causing the many symptoms listed above.<ref>https://en.wikipedia.org/wiki/MDP_syndrome#Genetics</ref> |
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== History == |
== History == |
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MDP syndrome was first described in 2010 when seven cases were reported by a group from Texas, USA. |
MDP syndrome was first described in 2010 when seven cases were reported by a group from Texas, USA.<ref>https://www.futurelearn.com/info/courses/diabetes-genomic-medicine/0/steps/10068</ref> |
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== Flag == |
== Flag == |
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The MDP Syndrome flag was coined by [[User:Reign of the breadsticcs|Reign of the breadsticcs]] on May 7th of 2021. It has no confirmed meaning. |
The MDP Syndrome flag was coined by [[User:Reign of the breadsticcs|Reign of the breadsticcs]] on May 7th of 2021. It has no confirmed meaning. |
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== References == |
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<references /> |
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* https://www.futurelearn.com/info/courses/diabetes-genomic-medicine/0/steps/10068#:~:text=MDP%20syndrome%20(Mandibular%20hypoplasia%2C%20Deafness,being%20stored%20underneath%20the%20skin. |
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* https://rarediseases.info.nih.gov/diseases/10989/mandibular-hypoplasia-deafness-progeroid-features-and-lipodystrophy-syndrome |
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* https://en.wikipedia.org/wiki/MDP_syndrome |
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*https://lgbta.wikia.org/f/p/4400000000000137332/r/4400000000000449105 |
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[[Category:Intersex Traits]] |
[[Category:Intersex Traits]] |
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[[Category:Sex Category]] |
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[[Category:Pages Without Resources]] |
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Latest revision as of 23:00, 26 March 2022
MDP Syndrome (Mandibular Hypoplasia-Deafness-Progeroid Syndrome) is an intersex variation that effects both CTF and CTM individuals alike.[1]
For CTM individuals, symptoms include absent or undescended testicles, AMAB hypogonadism, and possibly aromatase excess syndrome due to the lack of testosterone. This may cause low muscle tone, low hair growth, and possibly feminine traits within these individuals
For CTF individuals, symptoms include AFAB hypogonadism and possibly hyperandrogenism due to the lack of estrogen. This may cause a lack of breast growth and possibly masculine traits within these individuals.
In both CTF and CTM individuals, common symptoms include deafness or low hearing, low fat, insulin resistance, diabetes, tight skin, a small lower jaw, an enlarged liver, flexed joints, dental crowding, and possibly a beaked nose. Some of the symptoms may classify one with this variation as physically disabled.
Causes
This variation is caused by a single codon deletion the POLD1 gene, a gene that codes proteins and is present in all cells. This change can cause development in every cell to be different or impaired, causing the many symptoms listed above.[2]
History
MDP syndrome was first described in 2010 when seven cases were reported by a group from Texas, USA.[3]
Flag
The MDP Syndrome flag was coined by Reign of the breadsticcs on May 7th of 2021. It has no confirmed meaning.