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Revision as of 19:44, 10 October 2021
Leydig Cell Hypoplasia or LCH is an extremely rare intersex variation[1] that effects AMAB/CTM individuals in which the Leydig Cell (a cell that secretes androgens) is underdeveloped.[2]
The cells underdevelopment causes a decrease in androgens and may cause ones male traits to be more feminine in nature. One with this variation tends to have ambiguous genitals/fall on the agenital spectrum, hypospadias, decreased body hair, and decreased muscle tone. In rare cases, they may have a vagina. Often AMAB hypogonadism is seen in these individuals as well, which may cause them to also fall under aromatase excess syndrome.[3][4]