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'''Leydig Cell Hypoplasia''' or '''LCH''' is an extremely rare [[intersex]] variation that effects [[AMAB]]/[[CTM]] individuals in which the Leydig Cell (a cell that secretes androgens) is underdeveloped. |
'''Leydig Cell Hypoplasia''' or '''LCH''' is an extremely rare [[intersex]] variation<ref>https://medlineplus.gov/genetics/condition/leydig-cell-hypoplasia/#frequency</ref> that effects [[AMAB]]/[[CTM]] individuals in which the Leydig Cell (a cell that secretes androgens) is underdeveloped.<ref>https://en.wikipedia.org/wiki/Leydig_cell_hypoplasia</ref> |
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The cells underdevelopment causes a decrease in androgens and may cause ones male traits to be more [[feminine]] in nature. |
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⚫ | |||
One with this variation tends to have [[Ambiguous Genitalia|ambiguous genitals]], [[agenital|micropenis]], a penis with [[hypospadias]] and/or a bifid scrotum, decreased body hair, and [[Secondary Sex Agenesis|decreased muscle tone]]. In more extreme cases, they may have a vagina, with their testicles being small (microorchidism) and undescended (cryptorchidism). |
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It is important to note that not all the symptoms listed in this page are guaranteed to occur in someone with this variation, as someone may only experience one or several of these symptoms, yet still hold the variation. |
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⚫ | Often [[AMAB Hypogonadism|AMAB hypogonadism]] is seen in these individuals as well, which may cause them to also fall under [[Aromatase Excess Syndrome|aromatase excess syndrome]].<ref>https://medlineplus.gov/genetics/condition/leydig-cell-hypoplasia/</ref><ref>https://www.cell.com/ajhg/pdf/S0002-9297(07)62597-X.pdf</ref> |
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== History == |
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== References == |
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There is no confirmation of its original discovery, however it has been known since 1995. |
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<references /> |
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== Resources == |
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* https://medlineplus.gov/genetics/condition/leydig-cell-hypoplasia/#frequency |
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* https://en.wikipedia.org/wiki/Leydig_cell_hypoplasia |
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* https://www.cell.com/ajhg/pdf/S0002-9297(07)62597-X.pdf |
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[[Category:Intersex Traits]] |
[[Category:Intersex Traits]] |
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[[Category:Flagless Sexes]] |
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[[Category:Verified Resources]] |
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[[Category:Pages With No History Section]] |
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[[Category:Sex Category]] |
Latest revision as of 01:57, 25 January 2023
Leydig Cell Hypoplasia or LCH is an extremely rare intersex variation[1] that effects AMAB/CTM individuals in which the Leydig Cell (a cell that secretes androgens) is underdeveloped.[2]
The cells underdevelopment causes a decrease in androgens and may cause ones male traits to be more feminine in nature.
One with this variation tends to have ambiguous genitals, micropenis, a penis with hypospadias and/or a bifid scrotum, decreased body hair, and decreased muscle tone. In more extreme cases, they may have a vagina, with their testicles being small (microorchidism) and undescended (cryptorchidism).
Often AMAB hypogonadism is seen in these individuals as well, which may cause them to also fall under aromatase excess syndrome.[3][4]