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'''Leydig Cell Hypoplasia''' or '''LCH''' is an extremely rare [[intersex]] |
'''Leydig Cell Hypoplasia''' or '''LCH''' is an extremely rare [[intersex]] variation<ref>https://medlineplus.gov/genetics/condition/leydig-cell-hypoplasia/#frequency</ref> that effects [[AMAB]]/[[CTM]] individuals in which the Leydig Cell (a cell that secretes androgens) is underdeveloped.<ref>https://en.wikipedia.org/wiki/Leydig_cell_hypoplasia</ref> |
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The cells underdevelopment causes a decrease in androgens and may cause ones male traits to be more [[feminine]] in nature. |
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== History == |
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There is no confirmation of its original discovery, however it has been known since 1995. |
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One with this variation tends to have [[Ambiguous Genitalia|ambiguous genitals]], [[agenital|micropenis]], a penis with [[hypospadias]] and/or a bifid scrotum, decreased body hair, and [[Secondary Sex Agenesis|decreased muscle tone]]. In more extreme cases, they may have a vagina, with their testicles being small (microorchidism) and undescended (cryptorchidism). |
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== Resources == |
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Often [[AMAB Hypogonadism|AMAB hypogonadism]] is seen in these individuals as well, which may cause them to also fall under [[Aromatase Excess Syndrome|aromatase excess syndrome]].<ref>https://medlineplus.gov/genetics/condition/leydig-cell-hypoplasia/</ref><ref>https://www.cell.com/ajhg/pdf/S0002-9297(07)62597-X.pdf</ref> |
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== References == |
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* https://en.wikipedia.org/wiki/Leydig_cell_hypoplasia |
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<references /> |
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* https://www.cell.com/ajhg/pdf/S0002-9297(07)62597-X.pdf |
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[[Category:Intersex Traits]] |
[[Category:Intersex Traits]] |
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[[Category:Flagless Sexes]] |
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[[Category:Verified Resources]] |
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[[Category:Pages With No History Section]] |
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[[Category:Sex Category]] |
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Latest revision as of 01:57, 25 January 2023
Leydig Cell Hypoplasia or LCH is an extremely rare intersex variation[1] that effects AMAB/CTM individuals in which the Leydig Cell (a cell that secretes androgens) is underdeveloped.[2]
The cells underdevelopment causes a decrease in androgens and may cause ones male traits to be more feminine in nature.
One with this variation tends to have ambiguous genitals, micropenis, a penis with hypospadias and/or a bifid scrotum, decreased body hair, and decreased muscle tone. In more extreme cases, they may have a vagina, with their testicles being small (microorchidism) and undescended (cryptorchidism).
Often AMAB hypogonadism is seen in these individuals as well, which may cause them to also fall under aromatase excess syndrome.[3][4]