mNo edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[File:Kallman syndrome.jpg|thumb|200x200px|The Kallman Syndrome flag.]] |
[[File:Kallman syndrome.jpg|thumb|200x200px|The Kallman Syndrome flag.]] |
||
'''Kallman Syndrome''' is an [[intersex]] variation that can effect both [[CTM]] and [[CTF]] |
'''Kallman Syndrome''' is an [[intersex]] variation that can effect both [[CTM]] and [[CTF]] individuals. It is estimated to occur in 1 in every 30,000 [[AMAB]] individuals, and 1 in every 120,000 [[AFAB]] individuals, meaning it is more common amongst AMAB individuals.<ref>https://en.wikipedia.org/wiki/Kallmann_syndrome</ref> |
||
In CTM |
In CTM individuals, symptoms include [[Agenital|a micropenis, cryptorchidism]], and/or [[AMAB Hypogonadism|AMAB hypogonadism]]. They may also fall under [[Aromatase Excess Syndrome|aromatase excess syndrome]] due to the lack of testosterone, however this is not always the case. |
||
In CTF |
In CTF individuals, symptoms include [[Secondary Sex Agenesis|lack of breast growth]], unfinished puberty, lack of menstruation, and [[AFAB Hypogonadism|AFAB hypogonadism]]. They may also fall under [[hyperandrogenism]] due to the lack of estrogen, however this is not always the case. |
||
In both CTF and CTM |
In both CTF and CTM individuals, symptoms that may or may not occur include lack of muscle definition, a reduced or total lack of smell, neutral or complete deafness, possibility of color blindness, a missing kidney, poor coordination, hand synkinesis, a cleft lip, a split hand/foot, a shortened middle finger, and/or scoliosis.<ref>https://en.wikipedia.org/wiki/Kallmann_syndrome#Signs_and_symptoms</ref> |
||
It is important to note that not all the symptoms listed in this page are guaranteed to occur in someone with this variation, as someone may only experience one or several of these symptoms, yet still hold the variation. |
|||
== Causes == |
== Causes == |
||
Changes in more than twenty genes have been associated with Kallmann syndrome. Among the most common causes of the variation are mutations in the ''ANOS1'', ''CHD7'', ''FGF8'', ''FGFR1'', ''PROK2'', or ''PROKR2'' gene. In some cases, affected individuals have mutations in more than one of these genes. |
Changes in more than twenty genes have been associated with Kallmann syndrome. Among the most common causes of the variation are mutations in the ''ANOS1'', ''CHD7'', ''FGF8'', ''FGFR1'', ''PROK2'', or ''PROKR2'' gene. In some cases, affected individuals have mutations in more than one of these genes. |
||
Additionally, researchers have identified mutations in other genes that may contribute to the development and features of Kallmann syndrome, but are unlikely to cause the variation on their own. |
Additionally, researchers have identified mutations in other genes that may contribute to the development and features of Kallmann syndrome, but are unlikely to cause the variation on their own.<ref>https://medlineplus.gov/genetics/condition/kallmann-syndrome/#causes</ref> |
||
== History == |
== History == |
||
Kallmann Syndrome was first described by name in a paper published in 1944 by Franz Josef Kallmann, a German-American geneticist. |
Kallmann Syndrome was first described by name in a paper published in 1944 by Franz Josef Kallmann, a German-American geneticist.<ref>https://en.wikipedia.org/wiki/Kallmann_syndrome#History</ref> |
||
== Flag == |
== Flag == |
||
The ATR-16 Syndrome flag was coined by [[User:Reign of the breadsticcs|Reign of the breadsticcs]] on May 7th of 2021. It has no confirmed meaning. |
The ATR-16 Syndrome flag was coined by [[User:Reign of the breadsticcs|Reign of the breadsticcs]] on May 7th of 2021. It has no confirmed meaning.<ref>https://lgbta.wikia.org/f/p/4400000000000137332/r/4400000000000449105</ref> |
||
== Resources == |
|||
* https://en.wikipedia.org/wiki/Kallmann_syndrome |
|||
* https://medlineplus.gov/genetics/condition/kallmann-syndrome/#frequency |
|||
*https://lgbta.wikia.org/f/p/4400000000000137332/r/4400000000000449105 |
|||
== References == |
|||
<references /> |
|||
[[Category:Intersex Traits]] |
[[Category:Intersex Traits]] |
||
Revision as of 19:36, 10 October 2021
Kallman Syndrome is an intersex variation that can effect both CTM and CTF individuals. It is estimated to occur in 1 in every 30,000 AMAB individuals, and 1 in every 120,000 AFAB individuals, meaning it is more common amongst AMAB individuals.[1]
In CTM individuals, symptoms include a micropenis, cryptorchidism, and/or AMAB hypogonadism. They may also fall under aromatase excess syndrome due to the lack of testosterone, however this is not always the case.
In CTF individuals, symptoms include lack of breast growth, unfinished puberty, lack of menstruation, and AFAB hypogonadism. They may also fall under hyperandrogenism due to the lack of estrogen, however this is not always the case.
In both CTF and CTM individuals, symptoms that may or may not occur include lack of muscle definition, a reduced or total lack of smell, neutral or complete deafness, possibility of color blindness, a missing kidney, poor coordination, hand synkinesis, a cleft lip, a split hand/foot, a shortened middle finger, and/or scoliosis.[2]
Causes
Changes in more than twenty genes have been associated with Kallmann syndrome. Among the most common causes of the variation are mutations in the ANOS1, CHD7, FGF8, FGFR1, PROK2, or PROKR2 gene. In some cases, affected individuals have mutations in more than one of these genes.
Additionally, researchers have identified mutations in other genes that may contribute to the development and features of Kallmann syndrome, but are unlikely to cause the variation on their own.[3]
History
Kallmann Syndrome was first described by name in a paper published in 1944 by Franz Josef Kallmann, a German-American geneticist.[4]
Flag
The ATR-16 Syndrome flag was coined by Reign of the breadsticcs on May 7th of 2021. It has no confirmed meaning.[5]
References
- ↑ https://en.wikipedia.org/wiki/Kallmann_syndrome
- ↑ https://en.wikipedia.org/wiki/Kallmann_syndrome#Signs_and_symptoms
- ↑ https://medlineplus.gov/genetics/condition/kallmann-syndrome/#causes
- ↑ https://en.wikipedia.org/wiki/Kallmann_syndrome#History
- ↑ https://lgbta.wikia.org/f/p/4400000000000137332/r/4400000000000449105