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'''De La Chapelle Syndrome''' (also known as '''XX Male Syndrome''' or '''46, XX Testicular Disorder''') is an [[intersex]]
Most with this variation [[Agenital|have small testicles or a missing testicle]] or a urethra opening that is on a unusual spot of the genitals ([[hypospadias]].) On rare occasion, one with this variation may have [[Ambiguous Genitalia|ambiguous genitals]]. Because of this, they may have [[AMAB Hypogonadism]].
In about 80% of individuals with De La Chapelle Syndrome, the condition results from an abnormal exchange of genetic material between chromosomes while they were forming in the uterus, which causes the individual to have no Y chromosomes, or only partial Y chromosomes.▼
Many with this variation tend to be shorter than average and infertile, however with testosterone treatments ([[Hormone Replacement Therapy|HRT]]) one may have a higher chance at a more natural flow of growth during puberty.<ref>{{Archive|Site=web|URL=https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/xx-male-syndrome}}</ref> Breast growth may also occur in some with this variation.<ref>https://web.archive.org/web/20221230173653/https://en.wikipedia.org/wiki/XX_male_syndrome#Signs_and_symptoms</ref>
== History ==▼
A similar intersex variation is [[SERKAL Syndrome]].
▲In about 80% of individuals with De La Chapelle Syndrome, the
== References ==
<references />
[[Category:Intersex Traits]]
[[Category:Flagless Sexes]]
[[Category:Verified Resources]]
[[Category:Sex Category]]
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