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    17-AH Deficiency: Difference between revisions

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    [[File:17-ah 1.png|thumb|The 17-AH flag.]]
    [[File:17-ah 1.png|thumb|The 17-AH flag.]]
    [[File:17-ah flag.png|thumb|The alternate 17-AH flag.]]
    [[File:17-ah flag.png|thumb|The alternate 17-AH flag.]]
    '''17-AH Deficiency''' or '''17-Alpha-Hydroxylase Deficiency''' is an [[intersex]] variation in which the adrenal glands (the glands that regulate the production of certain hormones) do not properly function. Because of this, the reproductive system does not grow very strongly. This variation is estimated to effect one in a million individuals at birth.<ref>{{Archive|URL=2022.02.11-072905/https://medlineplus.gov/genetics/condition/17-alpha-hydroxylase-17-20-lyase-deficiency}}</ref>
    '''17-AH Deficiency''' or '''17-Alpha-Hydroxylase Deficiency (17α-OHD)''' is an [[intersex]] variation in which the adrenal glands (the glands that regulate the production of certain hormones) do not properly function. Because of this, the reproductive system does not grow very strongly. This variation is estimated to effect one in a million individuals at birth.<ref>{{Archive|URL=2022.02.11-072905/https://medlineplus.gov/genetics/condition/17-alpha-hydroxylase-17-20-lyase-deficiency}}</ref>


    Those with XX chromosomes ([[CTF]]) have abnormally small ovaries and an abnormally small uterus. Because of this, they [[Secondary Sex Agenesis|do not develop many secondary sex traits]] (such as breasts, pubic hair, or menstruation cycles.) From this, they are unable to conceive a child, and thus are infertile. They often fall under [[AFAB Hypogonadism]].
    Those with XX chromosomes ([[CTF]]) have abnormally small ovaries and an abnormally small uterus. Because of this, they [[Secondary Sex Agenesis|do not develop many secondary sex traits]] (such as breasts, pubic hair, or menstruation cycles.) From this, they are unable to conceive a child, and thus are infertile. They often fall under [[AFAB Hypogonadism]]. HRT may be used to regulate menstruation in CTF individuals.<ref>https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.6109</ref>


    Those with XY chromosomes ([[CTM]]) usually have [[Ambiguous Genitalia|ambiguous genitals]] or a vagina and thus are often mistaken as [[müllerian]]. Those that do have a penis often have a [[Agenital|micropenis, cryptorchidism,]] and/or [[hypospadias]]. They are also infertile and often fall under [[AMAB Hypogonadism]].
    Those with XY chromosomes ([[CTM]]) usually have [[Ambiguous Genitalia|ambiguous genitals]] or a vagina and thus are often mistaken as [[müllerian]]. Those that do have a penis often have a [[Agenital|micropenis, cryptorchidism,]] and/or [[hypospadias]]. They are also infertile and often fall under [[AMAB Hypogonadism]].

    Most with this variation experience high blood pressure and hypokalemia.<ref>[https://medlineplus.gov/genetics/condition/17-alpha-hydroxylase-17-20-lyase-deficiency/#:~:text=17%20alpha(%CE%B1)%2Dhydroxylase,and%20are%20important%20for%20reproduction. https://medlineplus.gov/genetics/condition/17-alpha-hydroxylase-17-20-lyase-deficiency/#:~:text=17%20alpha(%CE%B1)%2Dhydroxylase,and%20are%20important%20for%20reproduction.]</ref>


    == Causes ==
    == Causes ==
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