17-AH Deficiency: Difference between revisions

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17-AH Deficiency or 17-Alpha-Hydroxylase Deficiency (17α-OHD) is an intersex variation in which the adrenal glands (the glands that regulate the production of certain hormones) do not properly function. Because of this, the reproductive system does not grow very strongly. This variation is estimated to affect one in a million individuals at birth.

Those with XX chromosomes (CTF) have abnormally small ovaries and an abnormally small uterus. Because of this, they do not develop many secondary sex traits (such as breasts, pubic hair, or menstruation cycles.) From this, they are unable to conceive a child and thus are infertile. They often fall under AFAB Hypogonadism. HRT may be used to regulate menstruation in CTF individuals.^[1]

Those with XY chromosomes (CTM) usually have ambiguous genitals or a vagina and thus are often mistaken as müllerian. Those that do have a penis often have a micropenis, cryptorchidism, and/or hypospadias. They are also infertile and often fall under AMAB Hypogonadism.

Most with this variation experience high blood pressure and hypokalemia.

Causes

This variation is inherited in an autosomal recessive pattern, which means both parents have a copy of the gene mutation that causes this, and both of their genes combined are what affected the child when being conceived.

Flag

Anderson from Cryptocrew's system created the flag on April 25th, 2021. Blue represents wolffian-like traits, pink represents müllerian-like traits, purple represents ambiguous traits, yellow represents diversity, white represents community, and black represents abnormalities in size. The black design is supposed to resemble the uterus/ovaries and/or the wolffian reproductive system/testicles.

Anderson coined the alternate flag on the same day with the same meanings.

References

↑ https://web.archive.org/web/20230508075009/https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.6109

https://web.archive.org/web/20230508075006/https://medlineplus.gov/genetics/condition/17-alpha-hydroxylase-17-20-lyase-deficiency/

[1] ttps://web.archive.org/web/20230508075009/https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.6109

[1]

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 [[File:17-ah 1.png|thumb|The 17-AH flag.]]
 [[File:17-ah flag.png|thumb|The alternate 17-AH flag.]]
-'''17-AH Deficiency''' or '''17-alpha-hydroxylase deficiency''' is an [[intersex]] variation in which the adrenal glands- the glands that regulate the production of certain horomones- do not properly function. Because of this, the reproductive system does not grow very strongly. This variation is estimates to effect one in a million individuals at birth.
+'''17-AH Deficiency''' or '''17-Alpha-Hydroxylase Deficiency (17α-OHD)''' is an [[Intersex|intersex]] variation in which the adrenal glands (the glands that regulate the production of certain hormones) do not properly function. Because of this, the reproductive system does not grow very strongly. This variation is estimated to affect one in a million individuals at birth.
-Those with XX chromosomes ([[CTF]]) have abnormally small ovaries and an abnormally small uterus. Because of this, they [[Secondary Sex Agenesis|do not develop many secondary sex traits]], such as breasts, pubic hair, or menstruation cycles. From this, they are unable to conceive a child, and thus are infertile, and usually also fall under [[AFAB Hypogonadism]].
+Those with XX chromosomes ([[CTF]]) have abnormally small ovaries and an abnormally small uterus. Because of this, they [[Secondary Sex Agenesis|do not develop many secondary sex traits]] (such as breasts, pubic hair, or menstruation cycles.) From this, they are unable to conceive a child and thus are infertile. They often fall under [[AFAB Hypogonadism]]. [[Hormone Replacement Therapy|HRT]] may be used to regulate menstruation in CTF individuals.<ref>{{Archive|Site=web|URL=20230508075009/https://onlinelibrary.wiley.com/doi/full/10.1002/ccr3.6109}}</ref>
-Those with XY chromosomes ([[CTM]]) usually have [[Ambiguous Genitalia|ambiguous genitals]] or a vagina, and because of this, they are often mistaken as female. Those that do have a penis often have a [[Agenital|micropenis, cryptorchidism,]] and/or [[hypospadias]]. They are also infertile, and often fall under [[AMAB Hypogonadism]].
+Those with XY chromosomes ([[CTM]]) usually have ambiguous genitals or a vagina and thus are often mistaken as [[müllerian]]. Those that do have a penis often have a micropenis, cryptorchidism, and/or [[Hypospadias|hypospadias]]. They are also infertile and often fall under [[AMAB Hypogonadism]].
-It is important to note that not all the symptoms listed above are guaranteed to occur in someone with this variation, as someone may only experience one or several of these symptoms, yet still hold the variation.
+Most with this variation experience high blood pressure and hypokalemia.
-== Genetics ==
-This variation is inherited in an ''autosomal recessive pattern,'' which means both parents have a copy of the gene mutation that causes this, and both of their genes combined is what effected the child when being conceived.
-== Flag ==
+==Causes==
+This variation is inherited in an ''autosomal recessive pattern,'' which means both parents have a copy of the gene mutation that causes this, and both of their genes combined are what affected the child when being conceived.
-The flag was coined by Anderson from [[User:Cryptocrew|Cryptocrew's]] system on April 35th of 2021. Blue represents male-like traits, pink represents female traits, purple represents ambiguous traits, yellow represents diversity, white represents community, black represents abnormalities in size, and the black design is designed to resemble the uterus/ovaries and/or the male reproductive system/testicles.
+==Flag==
-The alternate flag was coined on the same day by Anderson, with the same meanings.
+Anderson from [[User:Cryptocrew|Cryptocrew]]'s system created the flag on April 25th, 2021. Blue represents [[wolffian]]-like traits, pink represents müllerian-like traits, purple represents ambiguous traits, yellow represents diversity, white represents community, and black represents abnormalities in size. The black design is supposed to resemble the uterus/ovaries and/or the wolffian reproductive system/testicles.
+Anderson coined the alternate flag on the same day with the same meanings.
-== Resources ==
+==References==
-* https://medlineplus.gov/genetics/condition/17-alpha-hydroxylase-17-20-lyase-deficiency/#synonyms
+<references/>
-*https://en.wikipedia.org/wiki/Congenital_adrenal_hyperplasia_due_to_17%CE%B1-hydroxylase_deficiency
+* {{Archive|Site=web|URL=20230508075006/https://medlineplus.gov/genetics/condition/17-alpha-hydroxylase-17-20-lyase-deficiency/}}
 [[Category:Intersex Traits]]
 [[Category:Verified Resources]]
+[[Category:Pages With No History Section]]