XXXY Syndrome

XXXY Syndrome is an intersex genetic condition characterized by a sex chromosome aneuploidy, where AMAB individuals have two extra X chromosomes. It is estimated that XXXY affects one in every 50,000 AMAB births. There is a wide variety of symptoms associated with this syndrome, including cognitive and behavioral problems, taurodontism, and infertility. Though it is often mistaken or compared to Klinefelter Syndrome, they are different in nature.

One with this condition usually also has hypogonadism, and they usually experience an inability or struggle to produce sperm, and may have many mental conditions, which may cause a struggle with education. They may also have one or more of the many traits listed below.


 * An increased distance between the eyes.
 * Skin folds of the upper eyelid.
 * An up-slanting opening between the eyelids.
 * Hooded eyelids.
 * An abnormally bent pinkie finger.
 * Short nail beds
 * Flat feet.
 * Double jointedness.
 * Prominent elbows and arms that rest closer to the body.
 * An abnormally small penis.

Many with this syndrome get HRT/testosterone injections in order to go through a more proper or an easier puberty.

Resources

 * https://en.wikipedia.org/wiki/XXXY_syndrome


 * https://medlineplus.gov/genetics/condition/48xxxy-syndrome/
 * https://www.rarechromo.org/media/information/Chromosome_X/XXXY%20syndrome%20FTNW.pdf