Denys-Drash Syndrome

Denys-Drash Syndrome (DDS) is an intersex trait that effects both CTF and CTM individuals. It has only around 150-200 reports, however it may be more frequent than this, just without notice. This condition is caused when one WT1 gene- a gene designed for connecting regions of DNA together- fails to properly function. Because of this, proteins that effect genitals and kidneys are effected during development in the womb.

Those with this condition have diffuse glomerulosclerosis, which is a condition that effects ones kidneys abilities to filter waste. Because of this, they have a 90% chance at gaining Wilms tumor, a rare kidney cancer.

CTM individuals with this condition may have a penis, however they often have ambiguous genitals, undescended testicles (cryptorchidism), or a vagina. Because of this, they typically are infertile and unable to bare children. They also typically have gonadal dysgenesis and/or AMAB hypogonadism as well.

CTF individuals with this condition have a vagina, while the only noticeable trait of DDS is their kidneys. Because of this, they are often diagnosed with other kidney-related conditions, rather than with DDS.

It is important to note that not all the symptoms listed in this page are guaranteed to occur in someone with this condition, as someone may only experience one or several of these symptoms, yet still hold the condition.

Flag
The flag was created on April 27, 2021 by FANDOM user Ariathatsme. The meaning goes as follows: Yellow for intersex spectrum, blue/grey for CTM individuals, pink/grey for CTF individuals, and white for unity and inclusivity.

Frasier Syndrome
Not to be confused with Fraser Syndrome.

Frasier Syndrome is an intersex condition that falls under DDS. It has the same cause (improper function of the WT1 gene) however it is less severe. The symptoms are the same as DDS, just less intense.

Resources

 * https://medlineplus.gov/genetics/condition/denys-drash-syndrome/#causes
 * https://en.wikipedia.org/wiki/Denys%E2%80%93Drash_syndrome
 * https://medlineplus.gov/genetics/condition/frasier-syndrome/#causes