Hypogonadism

Hypogonadism is a rare sex development disorder that leads to reduction in the functionality of one's gonads, whether it be testes, ovaries, or ovotestes leading to a reduction or complete block in production of sex hormones such as testosterone or estrogen.

The different variants of hypogonadism are:
 * AFAB Hypogonadism
 * AMAB Hypogonadism

Causes
This condition can be caused by multiple different conditions. These usually include the underdevelopment of glands, gland tumors, radiation issues that effected the glands, gland injury and gland infection, nutrional problems, high prolactin level, chronic illnesses, and medical conditions such as iron overload.

This condition can also be caused by severe stress or drug use, however those are the 'less natural' causes of it.

Resources

 * 1) https://medlineplus.gov/ency/article/000390.htm