Cytochrome PORD

Cytochrome PORD (CPORD) is an intersex condition that effects both CTM and CTF individuals alike. This condition is characterized by a mutation in horomones, which causes one to gain hypogonadism, and have a lack of testosterone and estrogen alike. It is unknown how common this condition is, as only 65 cases have been reported.

For those with this condition, ambiguous genitals and infertility is common amongst both CTM and CTF individuals.

For CTF individuals, amenorrhea, ovarian cysts, and hyperandrogenism is common. Because of this, CTF individuals tend to have masculinized traits that cause irregular menstruation, acne, excessive body hair, and weight gain.

Antley-Bixler Syndrome
Antley-Bixler Syndrome (ABS) is know as the more severe version of Cytochrome PORD. The symptoms are more prominent and dramatic in nature, and are often more obvious than CPORD.

Those with this condition may or may not experience the symptoms of CPORD, however they do have their own exclusive symptoms that are listed below. This condition can effect both CTF and CTM people, just as CPORD can.

Symptoms include disordered steroidogenesis, skeletal abnormalities, bowed thigh bones, a flattened mid-face, a prominent forehead, low set ears, unusually long fingers, locked elbows, intellectual disabilities, and slowed development are prominent. They also tend to either have ambiguous genitals or to be on the agenital spectrum, and are infertile.

Causes
This condition is caused by mutations in the POR gene, a gene that provides instructions for enzymes that play a critical role in steroid horomones. Because of this mutation, horomones such as testosterone and estrogen become very low in production, and don't balance correctly within the body.

Pregnancy
Individuals who are pregnant with children who have CPORD or ABS tend to develop some symptoms themselves while the baby is forming. This includes development of excessive body hair, acne, and a deepening voice. These changes slowly go away after the baby is delivered.

The reasoning for this is due to horomonal disturbance effecting not only the baby, but the carrier of the baby as well during development.

Resources

 * https://medlineplus.gov/genetics/condition/cytochrome-p450-oxidoreductase-deficiency/#causes