Klinefelter Syndrome

Klinefelter syndrome (KS) or 47,XXY syndrome is a variation of intersex affecting approximately 1/500 AMAB/CTM individuals, making it one of the most common chromosomal variations of intersex. It results from having two or more X chromosomes and one Y chromosome (XXY) rather than just XY.

Symptoms may include greater height, poor coordination, less body hair, decreased ability to gain muscle, breast growth, lower sex drive (unless they are on the ace-spectrum already), a micropenis, reduced fertility, and possibly AMAB hypogonadism. Symptoms are typically not noticed until puberty. Often, symptoms may be subtle and many people do not realize they are affected because of this.

It is important to note that not all the symptoms listed in this page are guaranteed to occur in someone with this variation, as someone may only experience one or several of these symptoms, yet still hold the variation.

History
The syndrome was first discovered from and named after American endocrinologist Harry Klinefelter. This took place in 1942, within Massachusetts General Hospital in Boston and was first described it in the same year. The account given by Klinefelter came to be known as Klinefelter syndrome as his name appeared first on the published paper. Considering the names of all three researchers, it is sometimes also called Klinefelter–Reifenstein–Albright syndrome.

In 1956, it was discovered that Klinefelter syndrome resulted from an extra chromosome. Plunkett and Barr found the sex chromatin body in cell nuclei of the body. This was further clarified as XXY in 1959 by Patricia Jacobs and John Anderson Strong. The first published report of a man with a 47,XXY karyotype was by Patricia Jacobs and John Strong at Western General Hospital in Edinburgh, Scotland, in 1959. This karyotype was found in a 24-year-old man who had signs of KS. Jacobs described her discovery of this first reported human or mammalian chromosome aneuploidy in her 1981 William Allan Memorial Award address. Lili Elbe, one of the early recipients of sex reassignment surgery, may have had Klinefelter Syndrome. John Randolph of Roanoke had a genetic variation, possibly Klinefelter syndrome, that left him beardless and with a soprano prepubescent voice throughout his life.

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Resources
https://en.wikipedia.org/wiki/Klinefelter_syndrome#History