Denys-Drash Syndrome

Denys-Drash Syndrome (DDS) is an intersex trait that effects both AFAB and AMAB individuals. It has only around 150-200 reports, however it may be more frequent than this, just without notice. This condition is caused when one WT1 gene- a gene designed for connecting regions of DNA together- fails to properly function. Because of this, proteins that effect genitals and kidneys are effected during development in the womb.

Those with this condition have diffuse glomerulosclerosis, which is a condition that effects ones kidneys abilities to filter waste. Because of this, they have a 90% chance at gaining Wilms tumor, a rare kidney cancer.

AMAB individuals with this condition may have a penis, however they often have ambiguous genitals, undescended testicles (cryptorchidism), or a vagina. Because of this, they typically are infertile and unable to bare children. They also typically have gonadal dysgenesis as well.

AFAB individuals with this condition have a vagina, while the only noticeable trait of DDS is their kidneys. Because of this, they are often diagnosed with other kidney-related conditions, rather than with DDS.

Frasier Syndrome
Frasier Syndrome is an intersex condition that falls under DDS. It has the same cause (improper function of the WT1 gene) however it is less severe. The symptoms are the same as DDS, just less intense.

Resources

 * https://medlineplus.gov/genetics/condition/denys-drash-syndrome/#causes
 * https://en.wikipedia.org/wiki/Denys%E2%80%93Drash_syndrome
 * https://medlineplus.gov/genetics/condition/frasier-syndrome/#causes