Gonadal Dysgenesis

Gonadal dysgenesis is an intersex bodily/corporeal variation of the atypical embryonic development of the gonads, with reproductive tissue replaced with dysfunctional, fibrous tissue, which is called streak gonads. Streak gonads are a form of aplasia, resulting in hormonal failure that manifests as sexual infantism and infertility, with no initiation of puberty and secondary sex characteristics.

One with this condition cannot ovulate as their reproductive tissue is not formed and is instead replaced with simple tissue. This is usually seen with people who have 45,X/46,XY Mosaicism or Turners syndrome, however it can be a condition amongst itself.

Swyer syndrome
Swyer Syndrome is a form of Gonadal Dysgenesis, typically it is where an AFAB individual with female genitals and a female reproductive system, however their gonads are functionless and is replaced with streak gonads. If left without HRT, they will not experience puberty.

The name was chosen to be named after the endocrinologist who first discovered it, Gerald Swyer.

History
Swyer syndrome was first described by G. I. M. Swyer in 1955 in a report of two cases.