Leydig Cell Hypoplasia

Leydig Cell Hypoplasia or LCH is an extremely rare intersex variation that effects AMAB/CTM individuals in which the Leydig Cell (a cell that secretes androgens) is underdeveloped. This underdevelopment causes a decrease in androgens and may cause ones male traits to be more feminine in nature. One with this variation tends to have ambiguous genitals or otherwise fall on the agenital spectrum, hypospadias, decreased body hair, and decreased muscle tone.

Often AMAB hypogonadism is seen in these individuals as well, which may cause them to also fall under aromatase excess syndrome.

It is important to note that not all the symptoms listed in this page are guaranteed to occur in someone with this variation, as someone may only experience one or several of these symptoms, yet still hold the variation.

Flag
The flag was created on April 27, 2021 by FANDOM user Ariathatsme. The meaning goes as follows: Blue-grey for CTM individuals and connection to masculinity, white for inclusivity and connection, yellow for the intersex spectrum, and pink mask for femininity shielding masculine traits.

History
There is no confirmation of its original discovery, however it has been known since 1995.

Resources

 * https://medlineplus.gov/genetics/condition/leydig-cell-hypoplasia/#frequency
 * https://en.wikipedia.org/wiki/Leydig_cell_hypoplasia
 * https://www.cell.com/ajhg/pdf/S0002-9297(07)62597-X.pdf