Leydig Cell Hypoplasia

Leydig Cell Hypoplasia or LCH is an extremely rare intersex trait that effects AMAB/CTM individuals in which the Leydig Cell (a cell that secretes androgens) is underdeveloped. This underdevelopment causes a decrease in androgens and may cause ones male traits to be more feminine in nature. One with this condition tends to have ambiguous genitals or otherwise fall on the agenital spectrum, hypospadias, decreased body hair, and decreased muscle tone.

History
There is no confirmation of its original discovery, however it has been known since 1995.

Resources

 * https://medlineplus.gov/genetics/condition/leydig-cell-hypoplasia/#frequency
 * https://en.wikipedia.org/wiki/Leydig_cell_hypoplasia
 * https://www.cell.com/ajhg/pdf/S0002-9297(07)62597-X.pdf